The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer’s Disease: A Systematic Review | Zendy

YaTing Chang | Zendy; WenNeng Chang | Zendy; NaiWen Tsai | Zendy; ChihCheng Huang | Zendy; ChiaTe Kung | Zendy; YuJih Su | Zendy; Wei-Che Lin | Zendy; BenChung Cheng | Zendy; Chih-Min Su | Zendy; Yi-Fang Chiang | Zendy; ChengHsien Lu | Zendy

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The Roles of Biomarkers of Oxidative Stress and Antioxidant in Alzheimer’s Disease: A Systematic Review

Author(s) -

YaTing Chang,

WenNeng Chang,

NaiWen Tsai,

ChihCheng Huang,

ChiaTe Kung,

YuJih Su,

Wei-Che Lin,

BenChung Cheng,

Chih-Min Su,

Yi-Fang Chiang,

ChengHsien Lu

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/182303

Subject(s) - oxidative stress , disease , lipid peroxidation , bioinformatics , medicine , web of science , alzheimer's disease , antioxidant , biomarker , biology , meta analysis , biochemistry

Purpose . Oxidative stress plays an important role in the pathogenesis of Alzheimer's disease (AD). This paper aims to examine whether biomarkers of oxidative stress and antioxidants could be useful biomarkers in AD, which might form the bases of future clinical studies. Methods . PubMed, SCOPUS, and Web of Science were systematically queried to obtain studies with available data regarding markers of oxidative stress and antioxidants from subjects with AD. Results and Conclusion . Although most studies show elevated serum markers of lipid peroxidation in AD, there is no sufficient evidence to justify the routine use of biomarkers as predictors of severity or outcome in AD.

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