The Role of Ubiquitination and Sumoylation in Diabetic Nephropathy | Zendy

Chenlin Gao | Zendy; Wei Huang | Zendy; Keizo Kanasaki | Zendy; Yong Xu | Zendy

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The Role of Ubiquitination and Sumoylation in Diabetic Nephropathy

Author(s) -

Chenlin Gao,

Wei Huang,

Keizo Kanasaki,

Yong Xu

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/160692

Subject(s) - mg132 , sumo protein , ubiquitin , diabetic nephropathy , oxidative stress , diabetes mellitus , downregulation and upregulation , cancer research , medicine , microbiology and biotechnology , proteasome , bioinformatics , biology , endocrinology , proteasome inhibitor , genetics , gene

Diabetic nephropathy (DN) is a common and characteristic microvascular complication of diabetes; the mechanisms that cause DN have not been clarified, and the epigenetic mechanism was promised in the pathology of DN. Furthermore, ubiquitination and small ubiquitin-like modifier (SUMO) were involved in the progression of DN. MG132, as a ubiquitin proteasome, could improve renal injury by regulating several signaling pathways, such as NF- κ B, TGF- β , Nrf2-oxidative stress, and MAPK. In this review, we summarize how ubiquitination and sumoylation may contribute to the pathology of DN, which may be a potential treatment strategy of DN.

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