GCKGene-Body Hypomethylation Is Associated with the Risk of Coronary Heart Disease | Zendy

Limin Xu | Zendy; Dawei Zheng | Zendy; Lingyan Wang | Zendy; Danjie Jiang | Zendy; Haibo Liu | Zendy; Leiting Xu | Zendy; Qi Liao | Zendy; Lina Zhang | Zendy; Panpan Liu | Zendy; Xinbao Shi | Zendy; Zhaoyang Wang | Zendy; Lebo Sun | Zendy; Qingyun Zhou | Zendy; Ni Li | Zendy; Yi Huang | Zendy; Yanping Le | Zendy; Meng Ye | Zendy; Guofeng Shao | Zendy; Shiwei Duan | Zendy

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GCKGene-Body Hypomethylation Is Associated with the Risk of Coronary Heart Disease

Author(s) -

Limin Xu,

Dawei Zheng,

Lingyan Wang,

Danjie Jiang,

Haibo Liu,

Leiting Xu,

Qi Liao,

Lina Zhang,

Panpan Liu,

Xinbao Shi,

Zhaoyang Wang,

Lebo Sun,

Qingyun Zhou,

Ni Li,

Yi Huang,

Yanping Le,

Meng Ye,

Guofeng Shao,

Shiwei Duan

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/151723

Subject(s) - dna methylation , methylation , cpg site , medicine , gene , algorithm , endocrinology , chemistry , gene expression , biochemistry , computer science

Objectives . Glucokinase encoded by GCK is a key enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Variants of GCK gene were shown to be associated with type 2 diabetes (T2D) and coronary heart disease (CHD). The goal of this study was to investigate the contribution of GCK gene-body methylation to the risk of CHD. Design and Methods . 36 patients (18 males and 18 females) and 36 age- and sex-matched controls were collected for the current methylation research. DNA methylation level of the CpG island (CGI) region on the GCK gene-body was measured through the sodium bisulfite DNA conversion and pyrosequencing technology. Results. Our results indicated that CHD cases have a much lower methylation level (49.77 ± 6.43%) compared with controls (54.47 ± 7.65%, P = 0.018). In addition, GCK gene-body methylation was found to be positively associated with aging in controls ( r = 0.443, P = 0.010). Conclusions . Our study indicated that the hypomethylation of GCK gene-body was significantly associated with the risk of CHD. Aging correlates with an elevation of GCK methylation in healthy controls.

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