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Hyperhomocysteinemia is strongly associated with cardiovascular diseases. Previous studies have shown that phytoestrogen  α -zearalanol can protect cardiovascular system from hyperhomocysteinemia and ameliorate the level of plasma total homocysteine; however, the underlying mechanisms remain to be clarified. The aim of this research is to investigate the possible molecular mechanisms involved in ameliorating the level of plasma homocysteine by  α -zearalanol. By the successfully established diet-induced hyperhomocysteinemia rat models, we found that, after  α -zearalanol treatment, the activity of cystathionine  β -synthase, the key enzyme in homocysteine metabolism, was significantly elevated and level of nitrative stress in liver was significantly reduced. In correlation with this, results also showed a decreased nitration level of cystathionine  β -synthase in liver. Together data implied that alleviation of plasma homocysteine level by phytoestrogen  α -zearalanol might be related to the reduction of cystathionine  β -synthase nitration.

biomed research international

Alleviation of Plasma Homocysteine Level by Phytoestrogen<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>α</mml:mi></mml:mrow></mml:math>-Zearalanol Might Be Related to the Reduction of Cystathionine<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:math>-Synthase Nitration

Alleviation of Plasma Homocysteine Level by Phytoestrogenα-Zearalanol Might Be Related to the Reduction of Cystathionineβ-Synthase Nitration