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This study evaluates  in vivo  and  in vitro  anti- Helicobacter pylori (H. pylori)  efficacy of silver nanoparticles (Ag-NPs) prepared via a cost-effective green chemistry route wherein  Peganum harmala  L. seeds extract was used as a reducing and capping agent. The structural features, as elucidated by surface plasmon resonance spectrophotometry, transmission electron microscopy, and powder X-ray diffraction spectroscopy, revealed the Ag-NPs synthesized to be polydispersed in nature and spherical in shape with 5–40 nm size. A typical Ag-NPs suspension (S 5 ), with size being 15 nm, when tested  in vitro  against forty-two local isolates and two reference strains, showed a considerable anti -H. pylori  activity. In case of  in vivo  trial against  H. pylori  induced gastritis, after oral administration of 16 mg/kg body weight of S 5  for seven days, a complete clearance was recorded in male albino rates. In comparative time-killing kinetics, S 5  exhibited dose- and time-dependent anti- H. pylori  activity that was almost similar to tetracycline and clarithromycin, less than amoxicillin, but higher than metronidazole. Furthermore, S 5  was found to be an equally effective anti- H. pylori  agent at low (≤4) and high pH with no drug resistance observed even up to 10 repeated exposures while a significant drug resistance was recorded for most of the standard drugs employed. The present results revealed the potential of the synthesized Ag-NPs as safer bactericidal agents for the treatment of  H. pylori  induced gastritis.

bioinorganic chemistry and applications/bioinorganic chemistry and applications

Green Synthesis of Silver Nanoparticles: Structural Features andIn VivoandIn VitroTherapeutic Effects againstHelicobacter pyloriInduced Gastritis