Analytical Method Development and Validation of Solifenacin in Pharmaceutical Dosage Forms by RP-HPLC | Zendy

Rihana Parveen Shaik | Zendy; Srinivasa Babu Puttagunta | Zendy; Chandrasekar Kothapalli Bannoth | Zendy; Bala Sekhara Reddy Challa | Zendy

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Analytical Method Development and Validation of Solifenacin in Pharmaceutical Dosage Forms by RP-HPLC

Author(s) -

Rihana Parveen Shaik,

Srinivasa Babu Puttagunta,

Chandrasekar Kothapalli Bannoth,

Bala Sekhara Reddy Challa

Publication year - 2014

Publication title -

isrn analytical chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-732X

pISSN - 2090-7311

DOI - 10.1155/2014/132020

Subject(s) - dosage form , chromatography , monobasic acid , high performance liquid chromatography , triethylamine , chemistry , chromatography detector , solifenacin , methanol , medicine , organic chemistry , alternative medicine , pathology , overactive bladder

A new, accurate, precise, and robust HPLC method was developed and validated for the determination of solifenacin in tablet dosage form. The chromatographic separation was achieved on an Inertsil ODS 3V C 18 (150 mm × 4.6 mm, 5 μ m) stationary phase maintained at ambient temperature with a mobile phase combination of monobasic potassium phosphate (pH 3.5) containing 0.1% triethylamine and methanol (gradient mode) at a flow rate of 1.5 mL/min, and the detection was carried out by using UV detector at 220 nm. The performance of the method was validated according to the present ICH guidelines.

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