Open AccessDual Wavelength Spectrophotometric Method for Simultaneous Estimation of Atorvastatin Calcium and Felodipine from Tablet Dosage Form
Author(s) -
Namdeo Jadhav,
Ramesh S. Kambar,
Sameer Nadaf
Publication year - 2014
Publication title -
advances in chemistry
Language(s) - English
Resource type - Journals
eISSN - 2356-6612
pISSN - 2314-7571
DOI - 10.1155/2014/131974
Subject(s) - distilled water , dosage form , chromatography , calibration curve , chemistry , solvent , acetonitrile , linearity , absorption (acoustics) , analytical chemistry (journal) , materials science , detection limit , physics , biochemistry , composite material , quantum mechanics
Atorvastatin calcium (ATR) and felodipine (FEL) are beneficial in combination for elderly people in management of hypertension and atherosclerosis. Aim of present study is to develop simple, accurate, and precise method for simultaneous quantitative estimation of ATR and FEL from combined tablet dosage form. Method involves simultaneous equation, using acetonitrile—double distilled water (70 : 30)—common solvent showing absorption maxima at 245 and 268 nm. Calibration curves determination for both drugs has been carried out in 0.1 N HCl, phosphate buffer pH 6.8, and acetonitrile (ACN)—water (70 : 30 V/V). Linearity range was observed in the concentration range of 2 to 12 µg/mL for FEL and 20 to 100 µg/mL for ATR. Percent concentration estimated for ATR and FEL was 100.12 ± 1.03 and 99.98 ± 0.98, respectively. The method was found to be simple, economical, accurate and precise and can be used for quantitative estimation of ATR and FEL
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