Recombinant nAG (a Salamander-Derived Protein) Decreases the Formation of Hypertrophic Scarring in the Rabbit Ear Model | Zendy

Mohammad M. AlQattan | Zendy; Mervat M. Abd-Al Wahed | Zendy; Khalid Hawary | Zendy; Ahmed Alhumidi | Zendy; Medhat K. Shier | Zendy

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Recombinant nAG (a Salamander-Derived Protein) Decreases the Formation of Hypertrophic Scarring in the Rabbit Ear Model

Author(s) -

Mohammad M. AlQattan,

Mervat M. Abd-Al Wahed,

Khalid Hawary,

Ahmed Alhumidi,

Medhat K. Shier

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/121098

Subject(s) - hypertrophic scar , recombinant dna , collagenase , decorin , transfection , biology , muscle hypertrophy , microbiology and biotechnology , anatomy , endocrinology , extracellular matrix , gene , enzyme , proteoglycan , biochemistry

nAG (newt-Anterrior Gradient) protein is the key mediator of regrowth of amputated limbs in salamanders. In a previous work in our lab, a new nAG gene (suitable for humans) was designed and cloned. The cloned vector was transfected into primary human fibroblasts. The expression of nAG in human primary fibroblasts was found to suppress collagen expression. The current study shows that local injection of recombinant nAG reduces scar hypertrophy in the rabbit ear model. This is associated with lower scar elevation index (SEI), lower levels of collagen I & III, higher levels of MMP1, and a higher degree of scar maturation in experimental wounds compared to controls.

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