Value of Fused18F-Choline-PET/MRI to Evaluate Prostate Cancer Relapse in Patients Showing Biochemical Recurrence after EBRT: Preliminary Results | Zendy

Arnoldo Piccardo | Zendy; Francesco Paparo | Zendy; Riccardo Picazzo | Zendy; Mehrdad Naseri | Zendy; Paolo Ricci | Zendy; Andrea Marziano | Zendy; Lorenzo Bacigalupo | Zendy; Ennio Biscaldi | Zendy; Gian Andrea Rollandi | Zendy; Grillo Ruggieri F | Zendy; Mohsen Farsad | Zendy

Open Access

Value of Fused¹⁸F-Choline-PET/MRI to Evaluate Prostate Cancer Relapse in Patients Showing Biochemical Recurrence after EBRT: Preliminary Results

Author(s) -

Arnoldo Piccardo,

Francesco Paparo,

Riccardo Picazzo,

Mehrdad Naseri,

Paolo Ricci,

Andrea Marziano,

Lorenzo Bacigalupo,

Ennio Biscaldi,

Gian Andrea Rollandi,

Grillo Ruggieri F,

Mohsen Farsad

Publication year - 2014

Publication title -

biomed research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.772

H-Index - 126

eISSN - 2314-6141

pISSN - 2314-6133

DOI - 10.1155/2014/103718

Subject(s) - nuclear medicine , medicine , prostate cancer , choline , pet ct , positron emission tomography , magnetic resonance imaging , standardized uptake value , lymph node , radiology , cancer , pathology

Purpose . We compared the accuracy of 18 F-Choline-PET/MRI with that of multiparametric MRI (mMRI), 18 F-Choline-PET/CT, 18 F-Fluoride-PET/CT, and contrast-enhanced CT (CeCT) in detecting relapse in patients with suspected relapse of prostate cancer (PC) after external beam radiotherapy (EBRT). We assessed the association between standard uptake value (SUV) and apparent diffusion coefficient (ADC). Methods . We evaluated 21 patients with biochemical relapse after EBRT. Patients underwent 18 F-Choline-PET/contrast-enhanced (Ce)CT, 18 F-Fluoride-PET/CT, and mMRI. Imaging coregistration of PET and mMRI was performed. Results . 18 F-Choline-PET/MRI was positive in 18/21 patients, with a detection rate (DR) of 86%. DRs of 18 F-Choline-PET/CT, CeCT, and mMRI were 76%, 43%, and 81%, respectively. In terms of DR the only significant difference was between 18 F-Choline-PET/MRI and CeCT. On lesion-based analysis, the accuracy of 18 F-Choline-PET/MRI, 18 F-Choline-PET/CT, CeCT, and mMRI was 99%, 95%, 70%, and 85%, respectively. Accuracy, sensitivity, and NPV of 18 F-Choline-PET/MRI were significantly higher than those of both mMRI and CeCT. On whole-body assessment of bone metastases, the sensitivity of 18 F-Choline-PET/CT and 18 F-Fluoride-PET/CT was significantly higher than that of CeCT. Regarding local and lymph node relapse, we found a significant inverse correlation between ADC and SUV-max. Conclusion . 18 F-Choline-PET/MRI is a promising technique in detecting PC relapse.

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