Novel Antimicrobial Agents: Fluorinated 2-(3-(Benzofuran-2-yl) pyrazol-1-yl)thiazoles | Zendy

Hanan A. Mohamed | Zendy; Ehab AbdelLatif | Zendy; Bakr F. AbdelWahab | Zendy; Ghada E. A. Awad | Zendy

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Novel Antimicrobial Agents: Fluorinated 2-(3-(Benzofuran-2-yl) pyrazol-1-yl)thiazoles

Author(s) -

Hanan A. Mohamed,

Ehab AbdelLatif,

Bakr F. AbdelWahab,

Ghada E. A. Awad

Publication year - 2013

Publication title -

international journal of medicinal chemistry

Language(s) - English

Resource type - Journals

eISSN - 2090-2069

pISSN - 2090-2077

DOI - 10.1155/2013/986536

Subject(s) - benzofuran , antimicrobial , combinatorial chemistry , chemistry , traditional medicine , medicine , organic chemistry

A new series of 2-pyrazolin-1-ylthiazoles 8a–d and 13–16 was synthesized by cyclization of N -thiocarboxamide-2-pyrazoline with different haloketones and 2,3-dichloroquinoxaline. The structures of the new compounds were confirmed by elemental analyses as well as NMR, IR, and mass spectral data. The newly synthesized compounds were evaluated for their antimicrobial activities, and also their minimum inhibitory concentration (MIC) against most of test organisms was performed. Amongst the tested ones, compound 8c displayed excellent antimicrobial activity.

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