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The molecular mechanism formation of secondary epiretinal membranes (ERMs) after proliferative diabetic retinopathy (PDR) or primary idiopathic ERMs is still poorly understood. Therefore, the present study focused on the assessment of  IGF1 ,  IGF1R , and  IGFBP3  mRNA levels in ERMs and PBMCs from patients with PDR. The examined group comprised 6 patients with secondary ERMs after PDR and the control group consisted of 11 patients with idiopathic ERMs. Quantification of  IGF1 ,  IGF1R , and  IGFBP3  mRNAs was performed by real-time QRT-PCR technique. In ERMs,  IGF1  and  IGF1R  mRNA levels were significantly higher in patients with diabetes compared to control subjects. In PBMCs, there were no statistically significant differences of  IGF1 ,  IGF1R , and  IGFBP3  expression between diabetic and nondiabetic patients. In conclusion, our study indicated  IGF1  and  IGF1R  differential expression in ERMs, but not in PBMCs, of diabetic and nondiabetic patients, suggesting that these factors can be involved in the pathogenesis or progression of proliferative vitreoretinal disorders. This trial is registered with  NCT00841334 .

mediators of inflammation

Gene Expression ofIGF1,IGF1R, andIGFBP3in Epiretinal Membranes of Patients with Proliferative Diabetic Retinopathy: Preliminary Study