The Protective Effect of Cordymin, a Peptide Purified from the Medicinal MushroomCordyceps sinensis, on Diabetic Osteopenia in Alloxan-Induced Diabetic Rats | Zendy

Qi Wei | Zendy; Yang Zhang | Zendy; YaBo Yan | Zendy; Wei Lei | Zendy; Zixiang Wu | Zendy; Ning Liu | Zendy; Shuai Liu | Zendy; Lei Shi | Zendy; Yong Fan | Zendy

Open Access

The Protective Effect of Cordymin, a Peptide Purified from the Medicinal MushroomCordyceps sinensis, on Diabetic Osteopenia in Alloxan-Induced Diabetic Rats

Author(s) -

Qi Wei,

Yang Zhang,

YaBo Yan,

Wei Lei,

Zixiang Wu,

Ning Liu,

Shuai Liu,

Lei Shi,

Yong Fan

Publication year - 2013

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2013/985636

Subject(s) - osteopenia , alloxan , medicine , diabetes mellitus , endocrinology , antioxidant , bone mineral , osteoporosis , alkaline phosphatase , intraperitoneal injection , chemistry , biochemistry , enzyme

The aim of this study was to investigate the protective effect of cordymin on diabetic osteopenia in alloxan-induced diabetic rats and the possible mechanisms involved. The diabetic rats received daily intraperitoneal injection with cordymin (20, 50, and 100 mg/kg/day) for 5 weeks. Cordymin could restore the circulating blood glucose, glycosylated hemoglobin (HbA1c), serum alkaline phosphatase (ALP), tartrate resistant acid phosphatase (TRAP), and insulin levels in a dose-dependent manner. Also, the treatment of diabetic rats with cordymin could partially reverse the β cells death and decrease the total antioxidant status (TAOS) in the diabetic rats. The results may directly and indirectly account for the possible mechanism of the beneficial effect of cordymin on diabetic osteopenia, which was confirmed with the increased bone mineral content (BMC) and bone mineral density (BMD) in diabetic rats ( P < 0.05). All those findings indicate that cordymin may play a protective role in diabetic osteoporosis.

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