Metabolic Alterations of the Zebrafish Brain after Acute Alcohol Treatment by1H Nuclear Magnetic Resonance Spectroscopy | Zendy

DongCheol Woo | Zendy; GooYoung Kim | Zendy; Hyunju Kim | Zendy; Eunjung Bang | Zendy; Hyangshuk Rhim | Zendy; Sang-Young Kim | Zendy; DoWan Lee | Zendy; ChiBong Choi | Zendy; Youl-Hun Seoung | Zendy; BoYoung Choe | Zendy

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Metabolic Alterations of the Zebrafish Brain after Acute Alcohol Treatment by¹H Nuclear Magnetic Resonance Spectroscopy

Author(s) -

DongCheol Woo,

GooYoung Kim,

Hyunju Kim,

Eunjung Bang,

Hyangshuk Rhim,

Sang-Young Kim,

DoWan Lee,

ChiBong Choi,

Youl-Hun Seoung,

BoYoung Choe

Publication year - 2013

Publication title -

journal of spectroscopy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.323

H-Index - 21

eISSN - 2314-4920

pISSN - 2314-4939

DOI - 10.1155/2013/971914

Subject(s) - alcohol , zebrafish , ethanol , nuclear magnetic resonance spectroscopy , glutamate receptor , medicine , chemistry , endocrinology , pharmacology , biochemistry , receptor , stereochemistry , gene

The purpose of this study is to investigate the metabolic alterations associated with acute alcohol treatment in zebrafish by 1H nuclear magnetic resonance spectroscopy (NMRS). The brain metabolism of zebrafish was investigated after acute alcohol treatment (one-hour long exposure of adult fish to 0.00%, 0.25%, 0.50%, or 1.00% ethyl alcohol) with whole brain extraction. The results of this study showed that glutamate (Glu) was significantly decreased, scyllo-inositol (sIns) showed a small apparent increase only in the highest acute treatment dose group, and myoinositol (mIns) showed a significant decrease. [Glu]/[tCr] and [mIns]/[tCr] levels were significantly reduced regardless of the alcohol dose, and [sIns]/[tCr] was increased in the highest alcohol treatment dose group. The present NMR study revealed that specific metabolites, such as Glu and mIns, were substantially decreased in case of acute alcohol exposed zebrafish brain

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