Open AccessLow-Grade Inflammation and Spinal Cord Injury: Exercise as Therapy?
Author(s) -
Eduardo da Silva Alves,
Valdir de Aquino Lemos,
Francieli S. Ruiz,
Fábio Santos Lira,
Ronaldo Vagner Thomatieli dos Santos,
João Paulo Pereira Rosa,
Érico Chagas Caperuto,
Sérgio Tufik,
Marco Túlio de Mello
Publication year - 2013
Publication title -
mediators of inflammation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.37
H-Index - 97
eISSN - 1466-1861
pISSN - 0962-9351
DOI - 10.1155/2013/971841
Subject(s) - medicine , spinal cord injury , inflammation , spinal cord , immunosuppression , population , immune system , physical therapy , bioinformatics , immunology , environmental health , psychiatry , biology
An increase in the prevalence of obesity in people with spinal cord injury can contribute to low-grade chronic inflammation and increase the risk of infection in this population. A decrease in sympathetic activity contributes to immunosuppression due to the lower activation of immune cells in the blood. The effects of physical exercise on inflammatory parameters in individuals with spinal cord injury have not been well described. We conducted a review of the literature published from 1974 to 2012. This review explored the relationships between low-grade inflammation, spinal cord injury, and exercise to discuss a novel mechanism that might explain the beneficial effects of exercise involving an increase in catecholamines and cytokines in people with spinal cord injury.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom