The Bone Marrow Microenvironment as Niche Retreats for Hematopoietic and Leukemic Stem Cells | Zendy

Felix Nwajei | Zendy; Marina Konopleva | Zendy

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The Bone Marrow Microenvironment as Niche Retreats for Hematopoietic and Leukemic Stem Cells

Author(s) -

Felix Nwajei,

Marina Konopleva

Publication year - 2013

Publication title -

advances in hematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.371

H-Index - 31

eISSN - 1687-9112

pISSN - 1687-9104

DOI - 10.1155/2013/953982

Subject(s) - haematopoiesis , stem cell , niche , bone marrow , ecological niche , leukemia , stem cell niche , hematopoietic stem cell , microbiology and biotechnology , biology , medicine , immunology , progenitor cell , ecology , habitat

Leukemia poses a serious challenge to current therapeutic strategies. This has been attributed to leukemia stem cells (LSCs), which occupy endosteal and sinusoidal niches in the bone marrow similar to those of hematopoietic stem cells (HSCs). The signals from these niches provide a viable setting for the maintenance, survival, and fate specifications of these stem cells. Advancements in genetic engineering and microscopy have enabled us to critically deconstruct and analyze the anatomic and functional characteristics of these niches to reveal a wealth of new knowledge in HSC biology, which is quite ahead of LSC biology. In this paper, we examine the present understanding of the regulatory mechanisms governing HSC niches, with the goals of providing a framework for understanding the mechanisms of LSC regulation and suggesting future strategies for their elimination.

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