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BACKGROUND: Gonadoblastoma (GB) is regarded as an in situ form of germ cell tumor in dysgenetic gonads, and 30% of patients with GB develop a dysgerminoma/seminoma tumor.  OBJECTIVE: Determine whether OCT3/4 and β -catenin are expressed in dysgenetic gonads before GB development and whether TSPY participates in the OCT3/4- β -catenin pathways in the malignant invasive behavior.  METHODS: dysgenetic gonads of Disorders of sex differentiation (DSD) patients with mixed gonadal dysgenesis were analyzed by immunohistochemistry and immunofluorescence for comparison with GB and dysgerminoma/seminoma.  RESULTS: Our results suggest that the development of GB is secondary to the interaction of OCT3/4 and TSPY, that β -catenin does not participate in this process.  CONCLUSIONS: The use of this biological markers detects the potential high risk gonads.

disease markers

Utility of OCT3/4, TSPY and<i>β</i>-Catenin as Biological Markers for Gonadoblastoma Formation and Malignant Germ Cell Tumor Development in Dysgenetic Gonads

Utility of OCT3/4, TSPY andβ-Catenin as Biological Markers for Gonadoblastoma Formation and Malignant Germ Cell Tumor Development in Dysgenetic Gonads