Utility of OCT3/4, TSPY andβ-Catenin as Biological Markers for Gonadoblastoma Formation and Malignant Germ Cell Tumor Development in Dysgenetic Gonads | Zendy

Ícela Palma-Lara | Zendy; Nayely Garibay-Nieto | Zendy; Rocio Pena-Yolanda | Zendy; Alejandra ContrerasRamos | Zendy; Atlantida Raya | Zendy; Carolina Domínguez | Zendy; Mirna Romero | Zendy; Gerardo Aristi | Zendy; Gloria Queipo | Zendy

Open Access

Utility of OCT3/4, TSPY andβ-Catenin as Biological Markers for Gonadoblastoma Formation and Malignant Germ Cell Tumor Development in Dysgenetic Gonads

Author(s) -

Ícela Palma-Lara,

Nayely Garibay-Nieto,

Rocio Pena-Yolanda,

Alejandra ContrerasRamos,

Atlantida Raya,

Carolina Domínguez,

Mirna Romero,

Gerardo Aristi,

Gloria Queipo

Publication year - 2013

Publication title -

disease markers

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.912

H-Index - 66

eISSN - 1875-8630

pISSN - 0278-0240

DOI - 10.1155/2013/951751

Subject(s) - gonadoblastoma , dysgerminoma , seminoma , gonadal dysgenesis , testicular germ cell tumor , gonocyte , wnt signaling pathway , biology , germ cell , cancer research , pathology , medicine , ovary , endocrinology , genetics , chemotherapy , gene , karyotype , chromosome

BACKGROUND: Gonadoblastoma (GB) is regarded as an in situ form of germ cell tumor in dysgenetic gonads, and 30% of patients with GB develop a dysgerminoma/seminoma tumor. OBJECTIVE: Determine whether OCT3/4 and β -catenin are expressed in dysgenetic gonads before GB development and whether TSPY participates in the OCT3/4- β -catenin pathways in the malignant invasive behavior. METHODS: dysgenetic gonads of Disorders of sex differentiation (DSD) patients with mixed gonadal dysgenesis were analyzed by immunohistochemistry and immunofluorescence for comparison with GB and dysgerminoma/seminoma. RESULTS: Our results suggest that the development of GB is secondary to the interaction of OCT3/4 and TSPY, that β -catenin does not participate in this process. CONCLUSIONS: The use of this biological markers detects the potential high risk gonads.

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