Foxp3+Regulatory T Cells in Mouse Models of Type 1 Diabetes | Zendy

Cathleen Petzold | Zendy; Julia Riewaldt | Zendy; Deepika Watts | Zendy; Tim Sparwasser | Zendy; Sonja Schallenberg | Zendy; Karsten Kretschmer | Zendy

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Foxp3⁺Regulatory T Cells in Mouse Models of Type 1 Diabetes

Author(s) -

Cathleen Petzold,

Julia Riewaldt,

Deepika Watts,

Tim Sparwasser,

Sonja Schallenberg,

Karsten Kretschmer

Publication year - 2013

Publication title -

journal of diabetes research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.034

H-Index - 50

eISSN - 2314-6753

pISSN - 2314-6745

DOI - 10.1155/2013/940710

Subject(s) - foxp3 , nod , autoimmunity , nod mice , il 2 receptor , type 1 diabetes , regulatory t cell , biology , immune system , immunology , transcription factor , computational biology , t cell , diabetes mellitus , genetics , gene , endocrinology

Studies on human type 1 diabetes (T1D) are facilitated by the availability of animal models such as nonobese diabetic (NOD) mice that spontaneously develop autoimmune diabetes, as well as a variety of genetically engineered mouse models with reduced genetic and pathogenic complexity, as compared to the spontaneous NOD model. In recent years, increasing evidence has implicated CD4 + CD25 + regulatory T (Treg) cells expressing the transcription factor Foxp3 in both the breakdown of self-tolerance and the restoration of immune homeostasis in T1D. In this paper, we provide an overview of currently available mouse models to study the role of Foxp3 + Treg cells in the control of destructive β cell autoimmunity, including a novel NOD model that allows specific and temporally controlled deletion of Foxp3 + Treg cells.

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