English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background.  Acute inflammation and its timely resolution play important roles in the body's responses to the environmental stimulation. Although IFN- γ  is well known for the induction of inflammation, its role in the inflammation resolution is still poorly understood.  Methodology and Principal Findings.  In this study, we investigated the function of interferon gamma (IFN- γ ) during the resolution of PMA-induced skin inflammation  in vivo . The results revealed that the expression levels of IL-6, TNF- α , and monocyte chemoattractant protein 1 (MCP-1) in skin decreased during the resolution stage of PMA-induced inflammation, while IFN- γ  is still maintained at a relatively high level. Neutralization of endogenous IFN- γ  led to accelerated reduction of epidermal thickness and decreased epithelial cell proliferation. Similarly, decreased infiltration of inflammatory cells (Gr1 +  or CD11b +  cells) and a significant reduction of proinflammatory cytokines were also observed upon the blockade of IFN- γ . Furthermore, neutralization of IFN- γ  boosted ALOX15 expression of the skin during inflammation resolution. In accordance, application of lipoxin A4 (LXA4, a product of ALOX15) obtained a proresolution effect similar to neutralization of IFN- γ . These results demonstrated that through upregulating ALOX15-LXA4 pathway, blockage of IFN- γ  can promote the resolution of PMA-induced skin inflammation.

mediators of inflammation

Resolution of PMA-Induced Skin Inflammation Involves Interaction of IFN-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>γ</mml:mi></mml:mrow></mml:math>and ALOX15

Resolution of PMA-Induced Skin Inflammation Involves Interaction of IFN-γand ALOX15