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The activated nuclear factor-KappaB signaling pathway plays a critical role in inducing inflammatory injury. It has been reported that electroacupuncture could be an effective anti-inflammatory treatment. We aimed to explore the complex mechanism by which EA inhibits the activation of the NF-  κ  B signal pathway and ameliorate inflammatory injury in the short term; the effects of NEMO Binding Domain peptide for this purpose were compared. Focal cerebral I/R was induced by middle cerebral artery occlusion for 2 hrs. Total 380 male Sprague-Dawley rats are in the study. The neurobehavioral scores, infarction volumes, and the levels of IL-1  β   and IL-13 were detected. NF-  κ  B p65, I  κ  B  α  , IKK  α  , and IKK  β   were analyzed and the ability of NF-  κ  B binding DNA was investigated. The EA treatment and the NBD peptide treatment both reduced infarct size, improved neurological scores, and regulated the levels of IL-1  β   and IL-13. The treatment reduced the expression of IKK  α   and IKK  β   and altered the expression of NF-  κ  B p65 and I  κ  B  α   in the cytoplasm and nucleus; the activity of NF-  κ  B was effectively reduced. We conclude that EA treatment might interfere with the process of NF-  κ  B nuclear translocation. And it also could suppress the activity of NF-  κ  B signaling pathway to ameliorate the inflammatory injury after focal cerebral ischemia/reperfusion.

evidence-based complementary and alternative medicine

Electroacupuncture Could Regulate the NF-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi mathvariant="bold">κ</mml:mi></mml:mrow></mml:math>B Signaling Pathway to Ameliorate the Inflammatory Injury in Focal Cerebral Ischemia/Reperfusion Model Rats

Electroacupuncture Could Regulate the NF-κB Signaling Pathway to Ameliorate the Inflammatory Injury in Focal Cerebral Ischemia/Reperfusion Model Rats