A Practical Catalyst‐Free Synthesis of 6‐Amino‐4 Alkyl/Aryl‐3‐methyl‐2,4‐dihydropyrano[2,3‐c]pyrazole‐carbonitrile in Aqueous Medium | Zendy

Manisha Bihani | Zendy; Pranjal P. Bora | Zendy; Ghanashyam Bez | Zendy

Open Access

A Practical Catalyst‐Free Synthesis of 6‐Amino‐4 Alkyl/Aryl‐3‐methyl‐2,4‐dihydropyrano[2,3‐c]pyrazole‐carbonitrile in Aqueous Medium

Author(s) -

Manisha Bihani,

Pranjal P. Bora,

Ghanashyam Bez

Publication year - 2012

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.436

H-Index - 50

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2013/920719

Subject(s) - chemistry , malononitrile , ethyl acetoacetate , hydrazine (antidepressant) , pyrazole , aldehyde , catalysis , hydrate , aryl , boiling , organic chemistry , aqueous medium , ethanol , alkyl , methanol , aqueous solution , medicinal chemistry , chromatography

A completely green and improved method for the synthesis of 6-amino-4-aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-carbonitriles by a four-component reaction of a mixture of ethyl acetoacetate, hydrazine hydrate, aldehyde, and malononitrile in boiling water is reported. Similar synthesis starting from aliphatic aldehydes was carried out in water: ethanol (1 : 1) at reflux temperature without using any catalyst

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