Synthesis and Bioevaluation of Novel Imatinib Base Derivatives via 1,1′‐Carbonyldiimidazole Catalyst | Zendy

M. J. Patoliya | Zendy; G. J. Kharadi | Zendy

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Synthesis and Bioevaluation of Novel Imatinib Base Derivatives via 1,1′‐Carbonyldiimidazole Catalyst

Author(s) -

M. J. Patoliya,

G. J. Kharadi

Publication year - 2013

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.436

H-Index - 50

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2013/915381

Subject(s) - chemistry , catalysis , base (topology) , imatinib , combinatorial chemistry , stereochemistry , organic chemistry , cancer research , mathematical analysis , mathematics , myeloid leukemia , biology

A series of eleven compounds were synthesized from 6-methyl-N′-(4-(pyridine-3-yl)pyrimidin-2-yl)benzene-1,3-diamine with various substituted carboxylic acid under solvent-free conditions using 1,1′-carbonyldiimidazole (CDI) as a catalyst. The yields of compounds are more than 72%. All the compounds were characterized by physical, spectroscopic, and elemental analysis. Compound 8b exhibited good inhibition towards antimicrobial activity compared to the other compounds

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