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Background . High-producer TGF  β  1 genotypes are associated with severe lung disease in cystic fibrosis (CF), but studies combining IL-8, TNF  α  -, and TGF  β  1(+genotype) levels and their impact on CF lung disease are scarce.  Aim . Assessing the relationship between TGF  β  1, IL-8, and TNF-  α   and lung disease in CF in an exacerbation-free interval.  Methods . Twenty four patients delta F508 homozygous (median age 20.5 y, Shwachman score 75, FEV1(%) 83) and 8 controls (median age 27.5 y) were examined. TGF  β  1 was assessed in serum and induced sputum (IS) by ELISA, for IL-8 and TNF-  α   by chemiluminescence in IS and whole blood. Genotyping was performed for TGF  β  1 C−509T and T+869C utilizing RFLP.  Results . TGF  β  1 in IS (CF/controls median 76.5/59.1 pg/mL,  P  < 0.074) was higher in CF. There was a negative correlation between TGF  β  1 in serum and lung function (LF) (FEV1 ( r  = −0.488,  P  = 0.025), MEF 25 ( r  = −0.425,  P  = 0.055), and VC ( r  = −0.572,  P  = 0.007)). Genotypes had no impact on TGF  β  1 in IS, serum, and LF. In IS TGF  β  1 correlated with IL-8 ( r  = 0.593,  P  < 0.007) and TNF-  α   ( r  = 0.536,  P  < 0.018) in patients colonized by bacteria with flagellin.  Conclusion . TGF  β  1 in serum not in IS correlates with LF. In patients colonized by bacteria with flagellin, TGF  β  1 correlates with IL-8 and TNF-  α   in IS.

mediators of inflammation

Transforming Growth Factor<i>β</i>1 Genotypes in Relation to TGF<i>β</i>1, Interleukin-8, and Tumor Necrosis Factor Alpha in Induced Sputum and Blood in Cystic Fibrosis

Transforming Growth Factorβ1 Genotypes in Relation to TGFβ1, Interleukin-8, and Tumor Necrosis Factor Alpha in Induced Sputum and Blood in Cystic Fibrosis