The Effect of Polymer Content on the Non-Newtonian Behavior of Acetaminophen Suspension | Zendy

Eskandar Moghimipour | Zendy; Maryam Kouchak | Zendy; Anayatollah Salimi | Zendy; Saeed Bahrampour | Zendy; Somayeh Handali | Zendy

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The Effect of Polymer Content on the Non-Newtonian Behavior of Acetaminophen Suspension

Author(s) -

Eskandar Moghimipour,

Maryam Kouchak,

Anayatollah Salimi,

Saeed Bahrampour,

Somayeh Handali

Publication year - 2013

Publication title -

journal of drug delivery

Language(s) - English

Resource type - Journals

eISSN - 2090-3014

pISSN - 2090-3022

DOI - 10.1155/2013/907471

Subject(s) - carboxymethyl cellulose , rheology , materials science , thixotropy , suspension (topology) , chemical engineering , polymer , viscosity , chromatography , chemistry , sodium , composite material , mathematics , metallurgy , homotopy , pure mathematics , engineering

Acetaminophen is used as an analgesic and antipyretic agent. The aim of the study was evaluation of the effect of different polymers on rheological behavior of acetaminophen suspension. In order to achieve controlled flocculation, sodium chloride was added. Then structural vehicles such as carboxymethyl cellulose (CMC), polyvinyl pyrrolidone (PVP), tragacanth, and magnesium aluminum silicate (Veegum) were evaluated individually and in combination. Physical stability parameters such as sedimentation volume ( F ), redispersibility ( n ), and growth of crystals of the suspensions were determined. Also, the rheological properties of formulations were studied. The results of this study showed that the combination of suspending agents had the most physical stability and pseudoplastic behavior with some degree of thixotropy. Viscosity of suspensions was increased by adding NaCl 0.02%. Presence of PVP is necessary for improving rheological behavior of suspensions by NaCl. This may be related to the cross-linking between the carbonyl group in the PVP segment and Na + ions.

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