Raman Spectroscopic Analysis of H2O2-Stimulated Three-Dimensional Human Skin Models Containing Asian, Black, and Caucasian Melanocytes | Zendy

Shin-ichi Morita | Zendy; Sota Takanezawa | Zendy; Akira Date | Zendy; Shin Watanabe | Zendy; Yasushi Sako | Zendy

Open Access

Raman Spectroscopic Analysis of H₂O₂-Stimulated Three-Dimensional Human Skin Models Containing Asian, Black, and Caucasian Melanocytes

Author(s) -

Shin-ichi Morita,

Sota Takanezawa,

Akira Date,

Shin Watanabe,

Yasushi Sako

Publication year - 2012

Publication title -

journal of spectroscopy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.323

H-Index - 21

eISSN - 2314-4920

pISSN - 2314-4939

DOI - 10.1155/2013/903450

Subject(s) - raman spectroscopy , human skin , hydrogen peroxide , reactive oxygen species , chemistry , stimulation , biophysics , biochemistry , optics , biology , medicine , genetics , physics

Reactive oxygen species generated in dermal cells of human skin is related to skin disorders or diseases. In this study, Raman analysis effectively clarified the identities of three types of human skin models after the models were stimulated with hydrogen peroxide. With the Caucasian skin model, the major Raman bands underwent large intensity changes within 4-5 days of stimulation. With the Black skin model, the Raman bands remained almost unchanged. The changes in the Asian skin model were unique compared to those in the above two. Eumelanin and pheomelanin are probably the main compounds that differentiate dermal cells in terms of their sensitivity to hydrogen peroxide

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