Open AccessGene Expression Profiles at Moxibustioned Site (ST36): A Microarray Analysis
Author(s) -
Haiyan Yin,
Yong Tang,
Shengfeng Lu,
Ling Luo,
Jia-Ping Wang,
Xuguang Liu,
Shuguang Yu
Publication year - 2013
Publication title -
evidence-based complementary and alternative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.552
H-Index - 90
eISSN - 1741-4288
pISSN - 1741-427X
DOI - 10.1155/2013/890579
Subject(s) - zusanli , moxibustion , microarray analysis techniques , microarray , downregulation and upregulation , gene , biology , gene expression , gene chip analysis , gene expression profiling , pathological , medicine , pathology , genetics , electroacupuncture , acupuncture , alternative medicine
As a major alternative therapy in Traditional Chinese Medicine, it has been demonstrated that moxibustion could generate a series of molecular events in blood, spleen, and brain, and so forth. However, what would happen at the moxibustioned site remained unclear. To answer this question, we performed a microarray analysis with skin tissue taken from the moxibustioned site also Zusanli acupoint (ST36) where 15-minute moxibustion stimulation was administrated. The results exhibited 145 upregulated and 72 downregulated genes which responded immediately under physiological conditions, and 255 upregulated and 243 downregulated genes under pathological conditions. Interestingly, most of the pathways and biological processes of the differentially expressed genes (DEGs) under pathological conditions get involved in immunity, while those under physiological conditions are involved in metabolism.
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