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Objectives . To investigate how Xiao-Ai-Ping injection, a traditional Chinese medicine and an ancillary drug in tumor treatment, enhances the antitumor effects of cisplatin on Lewis lung cancer (LLC) cells.  Methods . LLC-bearing mice were daily intraperitoneally injected with various doses of cisplatin, Xiao-Ai-Ping, or cisplatin plus Xiao-Ai-Ping, respectively. Body weight and tumor volumes were measured every three days.  Results . Combination of Xiao-Ai-Ping and cisplatin yielded significantly better antigrowth and proapoptotic effects on LLC xenografts than sole drug treatment did. In addition, we found that Xiao-Ai-Ping triggered the infiltration of CD8 +  T cells, a group of cytotoxic T cells, to LLC xenografts. Furthermore, the mRNA levels of interferon-  γ   ( ifn-    γ  ), perforin-1 ( prf-1 ), and granzyme B ( gzmb ) in CD8 +  T cells were significantly increased after combination treatment of Xiao-Ai-Ping and cisplatin.  In vitro  studies showed that Xiao-Ai-Ping markedly upregulated the mRNA levels of  ifn-    γ  ,  prf-1,  and  gzmb  in CD8 +  T cells in a concentration-dependent manner, suggesting that Xiao-Ai-Ping augments the function of CD8 +  T cells.  Conclusions . Xiao-Ai-Ping promotes the infiltration and function of CD8 +  T cells and thus enhances the antigrowth effects of cisplatin on LLC xenografts, which provides new evidence for the combination of Xiao-Ai-Ping and cisplatin in clinic in China.

evidence-based complementary and alternative medicine

Xiao-Ai-Ping, a TCM Injection, Enhances the Antigrowth Effects of Cisplatin on Lewis Lung Cancer Cells through Promoting the Infiltration and Function of CD8<sup>+</sup>T Lymphocytes

Xiao-Ai-Ping, a TCM Injection, Enhances the Antigrowth Effects of Cisplatin on Lewis Lung Cancer Cells through Promoting the Infiltration and Function of CD8+T Lymphocytes

Xiao-Ai-Ping, a TCM Injection, Enhances the Antigrowth Effects of Cisplatin on Lewis Lung Cancer Cells through Promoting the Infiltration and Function of CD8⁺T Lymphocytes