Investigation of Charge Transfer Complexes Formed between Mirtazapine and Someπ-Acceptors | Zendy

Hülya Demirhan | Zendy; Mustafa Arslan | Zendy; Mustafa Zengin | Zendy; Mustafa Küçükislamoğlu | Zendy

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Investigation of Charge Transfer Complexes Formed between Mirtazapine and Someπ-Acceptors

Author(s) -

Hülya Demirhan,

Mustafa Arslan,

Mustafa Zengin,

Mustafa Küçükislamoğlu

Publication year - 2012

Publication title -

journal of spectroscopy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.323

H-Index - 21

eISSN - 2314-4920

pISSN - 2314-4939

DOI - 10.1155/2013/875953

Subject(s) - tetracyanoethylene , dichloromethane , chemistry , charge (physics) , tetracyanoquinodimethane , mirtazapine , stoichiometry , benzoquinone , analytical chemistry (journal) , medicinal chemistry , organic chemistry , physics , molecule , quantum mechanics , neuroscience , solvent , biology , hippocampus , antidepressant

Charge transfer complexes (CTC) of mirtazapine with tetracyanoethylene (TCNE), 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ), and tetracyanoquinodimethane (TCNQ) have been studied spectrophotometrically in dichloromethane at room temperature. The stoichiometries of the complexes were found to be 1 : 1 ratio by the Job Method between mirtazapine and the acceptors. The equilibrium constants and thermodynamic parameters of the complexes were determined by the Benesi-Hildebrand and Van't Hoff equations. Mirtazapine in pure and dosage form was applied in this study. The results indicate that the formation constants for the complexes depend on the nature of electron acceptors and donor. And also the spectral studies of the complexes were determined by FT-IR and NMR spectroscopy

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