Erectogenic and Aphrodisiac Effects ofButea frondosaKoenig ex Roxb. in Rats: Involvement of Enzyme Inhibition | Zendy

Sumanta Goswami | Zendy; Mohammed Naseeruddin Inamdar | Zendy; Manoj Kumar Pandre | Zendy; Rohitash Jamwal | Zendy; Shekhar Dethe | Zendy

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Erectogenic and Aphrodisiac Effects ofButea frondosaKoenig ex Roxb. in Rats: Involvement of Enzyme Inhibition

Author(s) -

Sumanta Goswami,

Mohammed Naseeruddin Inamdar,

Manoj Kumar Pandre,

Rohitash Jamwal,

Shekhar Dethe

Publication year - 2013

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2013/874894

Subject(s) - aphrodisiac , traditional medicine , chemistry , medicine , alternative medicine , pathology

Butea frondosa Koenig ex Roxb. (BF) is traditionally used to manage male sexual disorders including erectile dysfunction (ED). Methanol extract of BF (bark) inhibited Rho-kinase 2 (ROCK-II) enzyme activity in vitro with an IC 50 of 20.29 ± 1.83 μ g/mL. The relaxant effect of methanol extract of BF (MEBF) was studied on phenylephrine precontracted corpus cavernosum smooth muscle (CCSM) isolated from young rats. The effect of MEBF treatment on sexual behaviour of both young (5 month) and aged (24 month) rats was also studied in addition to the influence on smooth muscle, collagen (collagen-I and -III) level in penis, and sperm characteristics of young and aged rats. MEBF relaxed CCSM up to 21.77 ± 2.57% and increased sexual behavior of young and aged rats. This increase in sexual function could be attributed to ROCK-II inhibition and increase in ratio of smooth muscle to collagen level in rat penile tissue. Increased sperm production and decreased defective sperms in young and aged rats corroborate the usefulness of Butea frondosa in male infertility in addition to ED.

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