Squamous Cell Carcinoma of the Lung with Metastasis to the GI Tract Associated with EGFR Exon 19 Deletion | Zendy

Glen J. Weiss | Zendy; Agnes K. Liman | Zendy; Jeffrey W. Allen | Zendy; Philip Y. Cheung | Zendy; Rajesh Kukunoor | Zendy

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Squamous Cell Carcinoma of the Lung with Metastasis to the GI Tract Associated with EGFR Exon 19 Deletion

Author(s) -

Glen J. Weiss,

Agnes K. Liman,

Jeffrey W. Allen,

Philip Y. Cheung,

Rajesh Kukunoor

Publication year - 2013

Publication title -

case reports in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.2

H-Index - 20

eISSN - 1687-9627

pISSN - 1687-9635

DOI - 10.1155/2013/874836

Subject(s) - medicine , exon , epidermal growth factor receptor , lung , metastasis , gastrointestinal tract , tyrosine kinase , lung cancer , cancer research , mutation , oncology , pathology , receptor , cancer , gene , biology , biochemistry

We describe three confirmed cases of squamous cell carcinoma (SCC) of the lung with metastasis to the gastrointestinal (GI) tract, with two having epidermal growth factor receptor (EGFR) exon 19 deletions in all available specimens. One of these patients received EGFR tyrosine kinase directed therapy for a brief period with some symptom relief. Consideration of EGFR exon 19 mutation testing in SCC of the lung, particularly for those with GI tract metastasis, may identify this potentially drug-targetable entity.

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