HMG‐CoA Reductase Inhibitors from Monascus‐Fermented Rice | Zendy

Xuemei Li | Zendy; Chunli Liu | Zendy; Zhenwen Duan | Zendy; Shuren Guo | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

HMG‐CoA Reductase Inhibitors from Monascus‐Fermented Rice

Author(s) -

Xuemei Li,

Chunli Liu,

Zhenwen Duan,

Shuren Guo

Publication year - 2013

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.436

H-Index - 50

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2013/872056

Subject(s) - chemistry , monascus , lovastatin , reductase , fermentation , silica gel , hmg coa reductase , high performance liquid chromatography , chromatography , enzyme , column chromatography , red yeast rice , simvastatin , food science , biochemistry , cholesterol , pharmacology , medicine

Seven compounds were isolated from Monascus-fermented rice by column chromatography with silica gel and semiprep HPLC. Their structures were elucidated by extensive spectroscopic methods. All compounds displayed HMG-CoA reductase inhibitory potential, among them compound 7 exhibited strong inhibition with IC50 value comparable with lovastatin. In this study, two compounds (1 and 2) were obtained from natural source for the first time

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research