Dystrophic Cutaneous Calcification and Metaplastic Bone Formation due to Long Term Bisphosphonate Use in Breast Cancer | Zendy

Ali Murat Tatlı | Zendy; Şeyda Gündüz | Zendy; Sema Sezgin Göksu | Zendy; Deniz Arslan | Zendy; Mükremın Uysal | Zendy; Cumhur İbrahim Başsorgun | Zendy; Hasan Şenol Çoşkun | Zendy

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Dystrophic Cutaneous Calcification and Metaplastic Bone Formation due to Long Term Bisphosphonate Use in Breast Cancer

Author(s) -

Ali Murat Tatlı,

Şeyda Gündüz,

Sema Sezgin Göksu,

Deniz Arslan,

Mükremın Uysal,

Cumhur İbrahim Başsorgun,

Hasan Şenol Çoşkun

Publication year - 2013

Publication title -

case reports in oncological medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.173

H-Index - 7

eISSN - 2090-6714

pISSN - 2090-6706

DOI - 10.1155/2013/871917

Subject(s) - medicine , bisphosphonate , calcification , dystrophic calcification , breast cancer , cancer , dentistry , dermatology , osteoporosis , pathology

Bisphosphonates are widely used in the treatment of breast cancer with bone metastases. We report a case of a female with breast cancer presented with a rash around a previous mastectomy site and a discharge lesion on her right chest wall in August 2010. Biopsy of the lesion showed dystrophic calcification and metaplastic bone formation. The patient's history revealed a long term use of zoledronic acid for the treatment of breast cancer with bone metastasis. We stopped the treatment since we believed that the cutaneous dystrophic calcification could be associated with her long term bisphosphonate therapy. Adverse cutaneous events with bisphosphonates are very rare, and dystrophic calcification has not been reported previously. The dystrophic calcification and metaplastic bone formation in this patient are thought to be due to long term bisphosphonate usage.

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