Drug Resistance Pattern of MTB Isolates from PTB Patients | Zendy

Rajani Ranganath | Zendy; V. Kumar | Zendy; Ravi Ranganath | Zendy; Gangadhar Goud | Zendy; Veerabhadra Javali | Zendy

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Drug Resistance Pattern of MTB Isolates from PTB Patients

Author(s) -

Rajani Ranganath,

V. Kumar,

Ravi Ranganath,

Gangadhar Goud,

Veerabhadra Javali

Publication year - 2013

Publication title -

tuberculosis research and treatment

Language(s) - English

Resource type - Journals

eISSN - 2090-1518

pISSN - 2090-150X

DOI - 10.1155/2013/862530

Subject(s) - ethambutol , streptomycin , rifampicin , medicine , drug resistance , tuberculosis , virology , multiple drug resistance , mycobacterium tuberculosis , isoniazid , antibiotics , drug , microbiology and biotechnology , pharmacology , biology , pathology

Background . TB is a global pandemic disease. All TB control programs were not successful due to the emergence of multidrug resistance in M. tuberculosis strains. Objective of the present study was to detect the rate of MDR-MTB in this part of India. Methods . One hundred and thirty clinical MTB strains isolated from patients on treatment and confirmed as MTB by MPT64 antigen detection were tested for drug susceptibility against Streptomycin, INH, Rifampicin, and Ethambutol by MBBact automated system. Result . Thirty-two were MDRs (25.61%). 31.2%, 28%, 17.6%, and 21.6% were resistant to INH, RIF, Ethambutol, and Streptomycin, respectively. Resistance to either INH or Rifampicin was 20.8% and 13.88%, respectively. Combined INH and Rifampicin resistance was seen in 18.05% isolates. Conclusion . Drug resistance rate is high in patients treated previously and who have been irregular on treatment.

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