Synthesis of Substituted Thioureas and Their Sulfur Heterocyclic Systems ofp-Amino Salicylic Acid as Antimycobacterial Agents | Zendy

M. S. I. MAKKI | Zendy; Reda M. AbdelRahman | Zendy; Hassan M. Faidallah | Zendy; Khalid Ali Khan | Zendy

Open Access

Synthesis of Substituted Thioureas and Their Sulfur Heterocyclic Systems ofp-Amino Salicylic Acid as Antimycobacterial Agents

Author(s) -

M. S. I. MAKKI,

Reda M. AbdelRahman,

Hassan M. Faidallah,

Khalid Ali Khan

Publication year - 2012

Publication title -

journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.436

H-Index - 50

eISSN - 2090-9063

pISSN - 2090-9071

DOI - 10.1155/2013/862463

Subject(s) - chemistry , antimycobacterial , sulfur , salicylic acid , thiourea , organic chemistry , combinatorial chemistry , stereochemistry , biochemistry , tuberculosis , mycobacterium tuberculosis , medicine , pathology

A series of new N,N′-substituted thioureas (2, 6, and 8) and their sulfur heterocycles as thiobarbituric acids (3, 4, and 7), 2-thioxothiazoliodin-4-one (10), thiazolidin-4-one (11), 1,2,4-triazol-5-thione (14), and 1,3,4-thiadiazole (15) of p-Amino salicylic acid (PAS) have been synthesized from treatment with dithiocarbazinate (1, 5 and 12) followed by heterocyclization with dimethyl malonate, chloroacetic acid, and/or trifluoroacetic anhydride. The structures of the newly synthesized compounds were substantiated with IR, H1, and C13 NMR spectral data and elementary microanalyses. The in vitro antitubercular activity of synthesized compounds against M. tuberculosis strain H37Rv showed moderate-to-good activity

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