NLRP3 Inflammasome and MS/EAE | Zendy

Makoto Inoue | Zendy; Mari L. Shinohara | Zendy

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NLRP3 Inflammasome and MS/EAE

Author(s) -

Makoto Inoue,

Mari L. Shinohara

Publication year - 2013

Publication title -

autoimmune diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.681

H-Index - 32

eISSN - 2090-0422

pISSN - 2090-0430

DOI - 10.1155/2013/859145

Subject(s) - inflammasome , experimental autoimmune encephalomyelitis , multiple sclerosis , innate immune system , medicine , immunology , encephalomyelitis , immune system , neuroscience , inflammation , biology

Inflammasomes are cytosolic sensors that detect pathogens and danger signals in the innate immune system. The NLRP3 inflammasome is currently the most fully characterized inflammasome and is known to detect a wide array of microbes and endogenous damage-associated molecules. Possible involvement of the NLRP3 inflammasome (or inflammasomes) in the development of multiple sclerosis (MS) was suggested in a number of studies. Recent studies showed that the NLRP3 inflammasome exacerbates experimental autoimmune encephalomyelitis (EAE), an animal model of MS, although EAE can also develop without the NLRP3 inflammasome. In this paper, we discuss the NLRP3 inflammasome in MS and EAE development.

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