The Effect of Anti-Inflammatory and Antimicrobial Herbal Remedy PADMA 28 on Immunological Angiogenesis and Granulocytes Activity in Mice | Zendy

Dorota M. Radomska-Leśniewska | Zendy; Piotr Skopiński | Zendy; Marcin Niemcewicz | Zendy; Robert Zdanowski | Zendy; Sławomir Lewicki | Zendy; Janusz Kocik | Zendy; Ewa Skopińska-Różewska | Zendy; Wanda Stankiewicz | Zendy

Open Access

The Effect of Anti-Inflammatory and Antimicrobial Herbal Remedy PADMA 28 on Immunological Angiogenesis and Granulocytes Activity in Mice

Author(s) -

Dorota M. Radomska-Leśniewska,

Piotr Skopiński,

Marcin Niemcewicz,

Robert Zdanowski,

Sławomir Lewicki,

Janusz Kocik,

Ewa Skopińska-Różewska,

Wanda Stankiewicz

Publication year - 2013

Publication title -

mediators of inflammation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.37

H-Index - 97

eISSN - 1466-1861

pISSN - 0962-9351

DOI - 10.1155/2013/853475

Subject(s) - angiogenesis , medicine , pharmacology , antimicrobial , traditional medicine , in vivo , phagocytosis , splenocyte , immune system , immunology , biology , microbiology and biotechnology

PADMA 28 is a herbal multicompound remedy that originates from traditional Tibetan medicine and possesses anti-inflammatory, antioxidant, antimicrobial, angioprotecting, and wound healing properties. The aim of the present study was to evaluate the influence of this remedy on immunological angiogenesis and granulocytes metabolic activity in Balb/c mice. Mice were fed daily, for seven days, with 5.8 mg of PADMA (calculated from recommended human daily dose) or 0.085 mg (dose in the range of active doses of other herbal extracts studied by us previously). Results . Highly significant increase of newly formed blood vessels number in ex vivo cutaneous lymphocyte-induced angiogenesis test (LIA) after grafting of Balb/c splenocytes from both dosage groups to F1 hybrids (Balb/c × C3H); increase of blood lymphocytes and granulocytes number only in mice fed with lower dose of remedy; and significant suppression of metabolic activity (chemiluminescence test) of blood granulocytes in mice fed with higher dose of PADMA. Conclusion . PADMA 28 behaves as a good stimulator of physiological angiogenesis, but for this purpose it should be used in substantially lower doses than recommended by producers for avoiding the deterioration of granulocyte function.

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