Predictive Factors of Potential Malignant Transformation in Recurrent Calcifying Cystic Odontogenic Tumor: Review of the Literature | Zendy

Sepideh Mokhtari | Zendy; Zhaleh Mohsenifar | Zendy; Maedeh Ghorbanpour | Zendy

Open Access

Predictive Factors of Potential Malignant Transformation in Recurrent Calcifying Cystic Odontogenic Tumor: Review of the Literature

Author(s) -

Sepideh Mokhtari,

Zhaleh Mohsenifar,

Maedeh Ghorbanpour

Publication year - 2013

Publication title -

case reports in pathology

Language(s) - English

Resource type - Journals

eISSN - 2090-6781

pISSN - 2090-679X

DOI - 10.1155/2013/853095

Subject(s) - medicine , malignant transformation , histopathology , pathology , odontogenic tumor , odontogenic , immunohistochemistry

Calcifying cystic odontogenic tumor (CCOT) demonstrates considerable diversity in histopathology and clinical behavior. Ghost cell odontogenic carcinoma (GCOC) is the rare malignant counterpart of CCOT and it frequently arises from malignant transformation of a recurrent CCOT. In this paper, we present a case of CCOT and discuss its distinct histopathologic features in recurrence. Then, we will have a review on clinical, histopathological, and immunohistochemical aspects of GCOC in the literature. Predictive factors of malignant transformation in a benign CCOT will also be discussed.

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