Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver Failure | Zendy

Wei Cui | Zendy; Cui-Ming Sun | Zendy; Pei Liu | Zendy

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Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver Failure

Author(s) -

Wei Cui,

Cui-Ming Sun,

Pei Liu

Publication year - 2013

Publication title -

gastroenterology research and practice

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.622

H-Index - 45

eISSN - 1687-630X

pISSN - 1687-6121

DOI - 10.1155/2013/841707

Subject(s) - occludin , tight junction , medicine , blood–brain barrier , claudin , paracellular transport , edema , vascular permeability , barrier function , pathology , permeability (electromagnetism) , central nervous system , microbiology and biotechnology , biology , biochemistry , membrane

Brain edema in acute liver failure (ALF) remains lethal. Cytotoxic mechanisms associated with brain edema have been well recognized, but the role of vasogenic mechanisms of brain edema has not been explored. Intact tight junctions (TJs) between brain capillary endothelial cells are critical for normal BBB function. Recent reports found significant alterations in the tight junction elements including occludin and claudin-5, suggesting a vasogenic injury in the blood-brain barrier (BBB) integrity. However, the role of TJ in ALF has not been completely understood. This paper reviews the role of the paracellular tight junction in the increased selective BBB permeability that leads to brain edema in ALF and furthermore explores the effect of systemic inflammatory cytokines on the tight junction dysfunction.

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