dTGS: Method for Effective Components Identification from Traditional Chinese Medicine Formula and Mechanism Analysis | Zendy

Ji Luo | Zendy; Yinglong Ren | Zendy; Hao Gu | Zendy; Yi Wu | Zendy; Yun Wang | Zendy

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dTGS: Method for Effective Components Identification from Traditional Chinese Medicine Formula and Mechanism Analysis

Author(s) -

Ji Luo,

Yinglong Ren,

Hao Gu,

Yi Wu,

Yun Wang

Publication year - 2013

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2013/840427

Subject(s) - component (thermodynamics) , traditional chinese medicine , mechanism (biology) , disease , identification (biology) , wasting , grammar , computer science , type 2 diabetes mellitus , computational biology , medicine , traditional medicine , diabetes mellitus , natural language processing , psychology , linguistics , biology , alternative medicine , endocrinology , epistemology , physics , pathology , philosophy , botany , thermodynamics

Because of the complexity of the components in Traditional Chinese Medicine formula (TCM formula), it is still a challenge to identify its effective components, to elucidate the mechanism of the components, and to discover the relationship between components and therapy objectives. In this paper, a method called directed TCM grammar systems (dTGS) for effective component identification was proposed using entity grammar systems (EGS) as the theoretical framework. The component-disease relationship of a TCM formula (i.e., Bai-Hu decoction plus Wasting-Thirsting formula, BHDWT) and one disease (i.e., type 2 diabetes mellitus) treated with it was studied, and the effective component groups (ECGs) were identified. 19 compounds were found acting on 20 proteins in type 2 diabetes mellitus (T2D) disease network, and 15 compounds were determined as the candidate effective components. Results indicated that this method can be used to identify the effective components and provide an innovative way to elucidate the molecular mechanism of TCM formulas.

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