Polyethylene Glycols as Efficient Catalysts for the Oxidation of Xanthine Alkaloids by Ceric Ammonium Nitrate in Acetonitrile: A Kinetic and Mechanistic Approach | Zendy

S. Shylaja | Zendy; K. C. Rajanna | Zendy; K. Ramesh | Zendy; K. Rajendar Reddy | Zendy; P. Giridhar Reddy | Zendy

Open Access

Polyethylene Glycols as Efficient Catalysts for the Oxidation of Xanthine Alkaloids by Ceric Ammonium Nitrate in Acetonitrile: A Kinetic and Mechanistic Approach

Author(s) -

S. Shylaja,

K. C. Rajanna,

K. Ramesh,

K. Rajendar Reddy,

P. Giridhar Reddy

Publication year - 2013

Publication title -

advances in physical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.269

H-Index - 17

eISSN - 1687-7993

pISSN - 1687-7985

DOI - 10.1155/2013/835610

Subject(s) - ceric ammonium nitrate , xanthine , theobromine , chemistry , acetonitrile , hypoxanthine , catalysis , peg ratio , ammonium nitrate , theophylline , nuclear chemistry , inorganic chemistry , organic chemistry , copolymer , enzyme , medicine , finance , economics , endocrinology , polymer

Kinetics of oxidation of xanthine alkaloids, such as Xanthine (XAN), hypoxanthine (HXAN), caffeine (CAF), theophylline (TPL), and theobromine (TBR), have been studied with ceric ammonium nitrate (CAN) using poly ethylene glycols (PEG) as catalysts. Reaction obeyed first order kinetics in both [CAN] and [Xanthine alkaloid]. Highly sluggish CAN-xanthine alkaloid reactions (in acetonitrile media even at elevated temperatures) are enhanced in presence PEGs (PEG-200, -300, -400, -600). An increase in [PEG] increased the rate of oxidation linearly. This observation coupled with a change in absorption of CAN in presence of PEG, [H–(OCH2–CH2)n–O–NH4Ce(NO3)4(CH3CN)] (PEG bound CAN species), is considered to be more reactive than CAN. The mechanism of oxidation in PEG media has been explained by Menger-Portnoy’s enzymatic model

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