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In the present study, the effect of CP-001, a standardized herbal mixture of  Houttuynia cordata ,  Rehmannia glutinosa ,  Betula platyphylla , and  Rubus coreanus , on cytochrome P450 (CYP) enzyme-mediated drug metabolism was investigated  in vitro  to evaluate the potential for herb-drug interactions. CP-001 was tested at concentrations of 1, 3, 10, 30, and 100   μ  g/mL. A CYP-specific substrate mixture was incubated with CP-001 in human liver microsomes, and the metabolites generated by each CYP-specific metabolic reaction were measured by liquid chromatography-tandem mass spectrometry. CP-001 seemed to slightly inhibit some CYP isozymes, but the IC 50  values for all CYP isozymes were greater than 100   μ  g/mL. Furthermore, CP-001 did not exhibit time-dependent CYP inhibitory activities, indicating that it does not act as a mechanism-based inactivator of CYP enzymes. In conclusion, the effects of CP-001 on CYP isozyme activities were negligible at the concentrations tested. Therefore, the likelihood of herbal mixture-drug interaction is considered minimal.

evidence-based complementary and alternative medicine

The Evaluation of CP-001 (a Standardized Herbal Mixture ofHouttuynia cordata,Rehmannia glutinosa,Betula platyphylla, andRubus coreanus) for Cytochrome P450-Related Herb-Drug Interactions