Targeting Metabolism to Induce Cell Death in Cancer Cells and Cancer Stem Cells | Zendy

Claire Pecqueur | Zendy; Lisa Oliver | Zendy; Kristell Oizel | Zendy; Lisenn Lalier | Zendy; François M. Vallette | Zendy

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Targeting Metabolism to Induce Cell Death in Cancer Cells and Cancer Stem Cells

Author(s) -

Claire Pecqueur,

Lisa Oliver,

Kristell Oizel,

Lisenn Lalier,

François M. Vallette

Publication year - 2013

Publication title -

international journal of cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.587

H-Index - 53

eISSN - 1687-8884

pISSN - 1687-8876

DOI - 10.1155/2013/805975

Subject(s) - cancer stem cell , cancer , cancer cell , apoptosis , cancer research , stem cell , medicine , bioinformatics , tumor cells , biology , immunology , microbiology and biotechnology , biochemistry

Abnormal metabolism and the evasion of apoptosis are considered hallmarks of cancers. Accumulating evidence shows that cancer stem cells are key drivers of tumor formation, progression, and recurrence. A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes.

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