Potential Consequences of Essential Drug Shortages in Canada: Brain Abscess due toNocardia farcinicaAssociated with Dapsone Prophylaxis forPneumocystis jiroveciiPneumonia | Zendy

Terence Wuerz | Zendy; Eric J. Bow | Zendy; Matthew D. Seftel | Zendy

Open Access

Potential Consequences of Essential Drug Shortages in Canada: Brain Abscess due toNocardia farcinicaAssociated with Dapsone Prophylaxis forPneumocystis jiroveciiPneumonia

Author(s) -

Terence Wuerz,

Eric J. Bow,

Matthew D. Seftel

Publication year - 2013

Publication title -

canadian journal of infectious diseases and medical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.634

H-Index - 38

eISSN - 1918-1493

pISSN - 1712-9532

DOI - 10.1155/2013/805797

Subject(s) - dapsone , pneumocystis jirovecii , nocardia , nocardiosis , medicine , brain abscess , pneumocystis pneumonia , pneumonia , economic shortage , intensive care medicine , abscess , dermatology , surgery , biology , bacteria , linguistics , philosophy , government (linguistics) , genetics

In 2012, Canadian pharmacies experienced a shortage of trimethoprim-sulfamethoxazole tablets. Drug shortages may result in unintended clinical consequences such as infection with pathogens against which the alternative medication is ineffective. This is highlighted in the present article, which describes a case of brain abscess due to Nocardia species that developed while receiving dapsone as an alternative for prophylaxis against Pneumocystis jirovecii pneumonia in a highly immune-suppressed patient. Clinicians should be cognizant of these issues when prescribing alternative agents.

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