Open AccessSynthesis, Characterization, and Crystal Structures of Bis‐Imidazolium Salts and Respective Dinuclear Ag(I) N‐Heterocyclic Carbene Complexes: In Vitro Anticancer Studies against “Human Colon Cancer” and “Breast Cancer”
Author(s) -
Rosenani A. Haque,
Siti Fatimah Nasri,
Muhammad Adnan Iqbal,
Sawsan S. Al-Rawi,
Seyedeh Fatemeh Jafari,
Mohamed B. Khadeer Ahamed,
Amin Malik Shah Abdul Majid
Publication year - 2013
Publication title -
journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.436
H-Index - 50
eISSN - 2090-9063
pISSN - 2090-9071
DOI - 10.1155/2013/804683
Subject(s) - chemistry , carbene , cytotoxicity , in vitro , mtt assay , stereochemistry , hela , cell culture , cancer cell lines , single crystal , cancer , cancer cell , crystallography , biochemistry , catalysis , medicine , biology , genetics
This paper describes synthesis, characterization (NMR, FT-IR, microanalysis, and X-ray crystallography), in vitro anticancer activity of ortho/para-xylyl linked bis-imidazolium salts (4-5) and respective dinuclear Ag(I) N-heterocyclic carbene (NHC) complexes (6-7). All the compounds were tested for their cytotoxicity against human colorectal cancer (HCT 116) and breast cancer (MCF-7) cell lines. According to cell viability measurements using MTT assay, all the complexes (6-7) showed a dose-dependent cytotoxic activity against both the cell lines, whereas respective salts (4-5) proved to be inactive. The complexes (6-7) demonstrated significant activity with IC50 values range 5.6–20.3 μM for HCT 116 and 1.12–6.38 μM for MCF-7. 5-Fluorouracil was used as standard drug (IC50 = 5.9 μM) for HCT 116, whereas tamoxifen was used as standard drug for MCF-7 (IC50 = 14 μM) cell line
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom