The Effects of Exercise Training on Obesity-Induced Dysregulated Expression of Adipokines in White Adipose Tissue | Zendy

Takuya Sakurai | Zendy; Junetsu Ogasawara | Zendy; Takako Kizaki | Zendy; Shogo Sato | Zendy; Yoshinaga Ishibashi | Zendy; Motoko Takahashi | Zendy; Osamu Kobayashi | Zendy; Shuji Ohishi | Zendy; Jun’ichi Nagasawa | Zendy; Kazuto Takahashi | Zendy; Hitoshi Ishida | Zendy; Tetsuya Izawa | Zendy; Hideki Ohno | Zendy

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The Effects of Exercise Training on Obesity-Induced Dysregulated Expression of Adipokines in White Adipose Tissue

Author(s) -

Takuya Sakurai,

Junetsu Ogasawara,

Takako Kizaki,

Shogo Sato,

Yoshinaga Ishibashi,

Motoko Takahashi,

Osamu Kobayashi,

Shuji Ohishi,

Jun’ichi Nagasawa,

Kazuto Takahashi,

Hitoshi Ishida,

Tetsuya Izawa,

Hideki Ohno

Publication year - 2013

Publication title -

international journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.875

H-Index - 60

eISSN - 1687-8345

pISSN - 1687-8337

DOI - 10.1155/2013/801743

Subject(s) - adipokine , adiponectin , medicine , white adipose tissue , adipose tissue , endocrinology , inflammation , leptin , insulin resistance , type 2 diabetes , obesity , chemerin , tumor necrosis factor alpha , diabetes mellitus

Obesity is recognized as a risk factor for lifestyle-related diseases such as type 2 diabetes and cardiovascular disease. White adipose tissue (WAT) is not only a static storage site for energy; it is also a dynamic tissue that is actively involved in metabolic reactions and produces humoral factors, such as leptin and adiponectin, which are collectively referred to as adipokines. Additionally, because there is much evidence that obesity-induced inflammatory changes in WAT, which is caused by dysregulated expression of inflammation-related adipokines involving tumor necrosis factor- α and monocyte chemoattractant protein 1, contribute to the development of insulin resistance, WAT has attracted special attention as an organ that causes diabetes and other lifestyle-related diseases. Exercise training (TR) not only leads to a decrease in WAT mass but also attenuates obesity-induced dysregulated expression of the inflammation-related adipokines in WAT. Therefore, TR is widely used as a tool for preventing and improving lifestyle-related diseases. This review outlines the impact of TR on the expression and secretory response of adipokines in WAT.

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