A Novel del(20q) in Aggressive Nodal Marginal Zone Lymphoma | Zendy

Jason B. Kern | Zendy; Deiter J. Duff | Zendy; Jamie L. Odem | Zendy; Magda Esebua | Zendy; Lisa R. Smith | Zendy; Donald C. Doll | Zendy; Michael Wang | Zendy

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A Novel del(20q) in Aggressive Nodal Marginal Zone Lymphoma

Author(s) -

Jason B. Kern,

Deiter J. Duff,

Jamie L. Odem,

Magda Esebua,

Lisa R. Smith,

Donald C. Doll,

Michael Wang

Publication year - 2013

Publication title -

case reports in pathology

Language(s) - English

Resource type - Journals

eISSN - 2090-6781

pISSN - 2090-679X

DOI - 10.1155/2013/784176

Subject(s) - medicine , lymphoma , pathology , lymph node , follicular lymphoma , marginal zone , neck mass , bone marrow , biopsy , lymph , lymph node biopsy , cervical lymphadenopathy , b cell , immunology , antibody , disease

This is a case report of a previously undescribed 20q chromosomal deletion (del(20q)) in marginal zone lymphoma (MZL). A 54-year-old Caucasian male presented with an enlarging neck mass and multiple violaceous skin nodules over his chest. Biopsy of the neck mass and cervical lymph nodes revealed MZL. Cytogenetic evaluation of both lymph node and bone marrow tissue revealed del(20q). This was an unexpected finding, as del(20q) is associated with myelodysplastic syndromes and myeloproliferative neoplasms and rarely seen in diffuse large B-cell lymphoma, follicular lymphoma, and T-cell lymphoma, but has not previously been described in MZL. We describe the case presentation and histologic findings and discuss the significance of this novel finding.

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