In VitroandIn VivoEvaluation of Polyherbal Formulation against Russell’s Viper and Cobra Venom and Screening of Bioactive Components by Docking Studies | Zendy

G Sakthivel | Zendy; Amitabha Dey | Zendy; Kh. galleima | Zendy; Murthy Chavali | Zendy; R. S. Rimal Isaac | Zendy; Nidhan Singh | Zendy; Lokesh Deb | Zendy

Open Access

In VitroandIn VivoEvaluation of Polyherbal Formulation against Russell’s Viper and Cobra Venom and Screening of Bioactive Components by Docking Studies

Author(s) -

G Sakthivel,

Amitabha Dey,

Kh. galleima,

Murthy Chavali,

R. S. Rimal Isaac,

Nidhan Singh,

Lokesh Deb

Publication year - 2013

Publication title -

evidence-based complementary and alternative medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.552

H-Index - 90

eISSN - 1741-4288

pISSN - 1741-427X

DOI - 10.1155/2013/781216

Subject(s) - antidote , viper , venom , antivenom , traditional medicine , viper venoms , pharmacology , snake venom , in vivo , toxicology , chemistry , biology , medicine , toxicity , biochemistry , microbiology and biotechnology , organic chemistry

The present study emphasizes to reveal the antivenom activity of Aristolochia bracteolata Lam., Tylophora indica (Burm.f.) Merrill, and Leucas aspera S. which were evaluated against venoms of Daboia russelli russelli (Russell's viper) and Naja naja (Indian cobra). The aqueous extracts of leaves and roots of the above-mentioned plants and their polyherbal (1 : 1 : 1) formulation at a dose of 200 mg/kg showed protection against envenomed mice with LD 50 doses of 0.44 mg/kg and 0.28 mg/kg against Russell's viper and cobra venom, respectively. In in vitro antioxidant activities sample extracts showed free radical scavenging effects in dose dependent manner. Computational drug design and docking studies were carried out to predict the neutralizing principles of type I phospholipase A 2 (PLA 2 ) from Indian common krait venom. This confirmed that aristolochic acid and leucasin can neutralize type I PLA 2 enzyme. Results suggest that these plants could serve as a source of natural antioxidants and common antidote for snake bite. However, further studies are needed to identify the lead molecule responsible for antidote activity.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research