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The present study emphasizes to reveal the antivenom activity of  Aristolochia bracteolata  Lam.,  Tylophora indica  (Burm.f.) Merrill, and  Leucas aspera S.  which were evaluated against venoms of  Daboia russelli russelli  (Russell's viper) and  Naja naja  (Indian cobra). The aqueous extracts of leaves and roots of the above-mentioned plants and their polyherbal (1 : 1 : 1) formulation at a dose of 200 mg/kg showed protection against envenomed mice with LD 50  doses of 0.44 mg/kg and 0.28 mg/kg against Russell's viper and cobra venom, respectively. In  in vitro  antioxidant activities sample extracts showed free radical scavenging effects in dose dependent manner. Computational drug design and docking studies were carried out to predict the neutralizing principles of type I phospholipase A 2  (PLA 2 ) from Indian common krait venom. This confirmed that aristolochic acid and leucasin can neutralize type I PLA 2  enzyme. Results suggest that these plants could serve as a source of natural antioxidants and common antidote for snake bite. However, further studies are needed to identify the lead molecule responsible for antidote activity.

evidence-based complementary and alternative medicine

<i>In Vitro</i>and<i>In Vivo</i>Evaluation of Polyherbal Formulation against Russell’s Viper and Cobra Venom and Screening of Bioactive Components by Docking Studies

In VitroandIn VivoEvaluation of Polyherbal Formulation against Russell’s Viper and Cobra Venom and Screening of Bioactive Components by Docking Studies