Preparation of Polysaccharide-Based Microspheres by a Water-in-Oil Emulsion Solvent Diffusion Method for Drug Carriers | Zendy

Yodthong Baimark | Zendy; Yaowalak Srisuwan | Zendy

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Preparation of Polysaccharide-Based Microspheres by a Water-in-Oil Emulsion Solvent Diffusion Method for Drug Carriers

Author(s) -

Yodthong Baimark,

Yaowalak Srisuwan

Publication year - 2013

Publication title -

international journal of polymer science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.399

H-Index - 33

eISSN - 1687-9430

pISSN - 1687-9422

DOI - 10.1155/2013/761870

Subject(s) - emulsion , materials science , solvent , drug carrier , chitosan , diffusion , polysaccharide , microsphere , drug delivery , scanning electron microscope , chemical engineering , dextran , chromatography , chemistry , nanotechnology , organic chemistry , composite material , physics , engineering , thermodynamics

Polysaccharide-based microspheres of chitosan, starch, and alginate were prepared by the water-in-oil emulsion solvent diffusion method for use as drug carriers. Blue dextran was used as a water-soluble biomacromolecular drug model. Scanning electron microscopy showed sizes of the resultant microspheres that were approximately 100 μm or less. They were spherical in shape with a rough surface and good dispersibility. Microsphere matrices were shown as a sponge. Drug loading efficiencies of all the microspheres were higher than 80%, which suggested that this method has potential to prepare polysaccharide-based microspheres containing a biomacromolecular drug model for drug delivery applications

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