Hyaluronan-Based Three-Dimensional Microenvironment Potently Induces Cardiovascular Progenitor Cell Populations | Zendy

Jessica M. Gluck | Zendy; Jennifer Chyu | Zendy; Connor Delman | Zendy; Sepideh HeydarkhanHagvall | Zendy; W. Robb MacLellan | Zendy; Richard J. Shemin | Zendy

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Hyaluronan-Based Three-Dimensional Microenvironment Potently Induces Cardiovascular Progenitor Cell Populations

Author(s) -

Jessica M. Gluck,

Jennifer Chyu,

Connor Delman,

Sepideh HeydarkhanHagvall,

W. Robb MacLellan,

Richard J. Shemin

Publication year - 2013

Publication title -

isrn tissue engineering

Language(s) - English

Resource type - Journals

ISSN - 2314-4696

DOI - 10.1155/2013/752620

Subject(s) - progenitor cell , microbiology and biotechnology , progenitor , population , extracellular matrix , cell , endothelial progenitor cell , endothelial stem cell , chemistry , stem cell , cell fate determination , biology , mesenchymal stem cell , immunology , in vitro , medicine , biochemistry , environmental health , gene , transcription factor

The relationship between stem cell niches in vivo and their surrounding microenvironment is still relatively unknown. Recent advances have indicated that extrinsic factors within the cardiovascular progenitor cell niche influence maintenance of a multipotent state as well as drive cell-fate decisions. We have previously shown the direct effects of extracellular matrix (ECM) proteins and have now investigated the effects of dimension on the induction of a cardiovascular progenitor cell (CPC) population. We have shown here that the three-dimensionality of a hyaluronan-based hydrogel greatly induces a CPC population, as marked by Flk-1. We have compared the effects of a 3D microenvironment to those of conventional 2D cell culture practices and have found that the 3D microenvironment potently induces a progenitor cell state.

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