Pathophysiological Significance of Hepatic Apoptosis | Zendy

KeWei Wang | Zendy; Bingliang Lin | Zendy

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Pathophysiological Significance of Hepatic Apoptosis

Author(s) -

KeWei Wang,

Bingliang Lin

Publication year - 2012

Publication title -

isrn hepatology

Language(s) - English

Resource type - Journals

ISSN - 2314-4041

DOI - 10.1155/2013/740149

Subject(s) - apoptosis , cholestasis , cirrhosis , pathological , cancer research , medicine , liver injury , carcinogenesis , pathophysiology , pathology , bioinformatics , biology , cancer , biochemistry

Apoptosis is a classical pathological feature in liver diseases caused by various etiological factors such as drugs, viruses, alcohol, and cholestasis. Hepatic apoptosis and its deleterious effects exacerbate liver function as well as involvement in fibrosis/cirrhosis and carcinogenesis. An imbalance between apoptotic and antiapoptotic capabilities is a prominent characteristic of liver injury. The regulation of apoptosis and antiapoptosis can be a pivotal step in the treatment of liver diseases.

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