Effect ofL. usitatissimum(Flaxseed/Linseed) Fixed Oil against Distinct Phases of Inflammation | Zendy

Gaurav Kaithwas | Zendy; Dipak K. Majumdar | Zendy

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Effect ofL. usitatissimum(Flaxseed/Linseed) Fixed Oil against Distinct Phases of Inflammation

Author(s) -

Gaurav Kaithwas,

Dipak K. Majumdar

Publication year - 2013

Publication title -

isrn inflammation

Language(s) - English

Resource type - Journals

ISSN - 2090-8695

DOI - 10.1155/2013/735158

Subject(s) - linum , vascular permeability , inflammation , chemistry , linseed oil , biochemistry , pharmacology , biology , immunology , botany , food science , endocrinology

The present investigation summarizes the effect of Linum usitatissimum fixed oil against different phases of acute inflammatory reaction, namely, protein exudation, peritoneal capillary permeability, and leukocyte migration. The fixed oil exhibited dose-dependent inhibition of protein exudation vascular permeability, comparable to standard aspirin. The oil also inhibited the leukocyte migration in pleural exudates in a dose-dependent manner. Production of less vasodilatory (PGE 3 ) and chemotactic (LTB 5 ) eicosanoids through EPA (derived from linolenic acid) metabolism could account for the above observations.

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